Anti-Human CD23 Recombinant Antibody (Gomiliximab)
CAT#: TAB-231
Recombinant monoclonal antibody to CD23. Gomiliximab is a monoclonal antibody acting as an immunosuppressive drug for the treatment of allergic asthma. It targets the low affinity IgE receptor (FcεRII or CD23). The drug is a chimeric antibody from Macaca irus and Homo sapiens.
Tested Data
Gene Expression
WB
Figure 1 Anti-Human CD23 Recombinant Antibody (Gomiliximab) (TAB-231) in WB
Western blot analysis of TAB-231 was performed with Recombinant Human CD23 Protein onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-231 and HRP Anti-Human IgG as a secondary antibody. Chemiluminescent detection was performed.
ELISA
Figure 2 Anti-Human CD23 Recombinant Antibody (Gomiliximab) (TAB-231) in ELISA
ELISA analysis of TAB-231 was performed by coating with Recombinant Human CD23 Protein. Then blocked with BSA, and incubated with Anti-Human CD23 Antibody (TAB-231). The HRP-conjugated anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
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Normal Tissue
Figure 1 High expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8928/24032_A_9_8_val_selected.jpg
Normal Tissue
Figure 2 Low expression in endometrium 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8928/24032_B_4_3_val_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2624/6435_B_5_4.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2624/6435_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104921-FCER2
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- primate
- Derivation
- Chimeric (primate/human)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in WB, Neut, ELISA, IF, IP, FuncS, FC and most other immunological methods.
- CAS
- 357613-86-6
- Generic Name
- Gomiliximab
- UNII
- 8Z13S29R5A
Product Property
- Purity
- >95%, by SDS-PAGE with silver staining, under reducing conditions.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- Gomiliximab;357613-86-6;FCER2;Fc fragment of IgE, low affinity II, receptor for (CD23);CD23A, Fc fragment of IgE, low affinity II, receptor for (CD23A) , FCE2;low affinity immunoglobulin epsilon Fc receptor;CD23;CLEC4J;BLAST-2;CD23 antigen;fc-epsilon-RII;
- Gene ID
- 2208
- UniProt ID
- P06734
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(Creative Biolabs Cat# TAB-231, RRID: AB_3111889)
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Gomiliximab"
Afuco™ Anti-FCER2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-231)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD23. It is a monoclonal antibody acting as an immunosuppressive drug for the treatment of allergic asthma. It targets the low affinity IgE receptor (FcεRII or CD23). The drug is a chimeric antibody from Macaca irus and Homo sapiens.
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